The Keratin 5 &14 Antibody from MyBioSource.com is a Mouse Monoclonal antibody to CK14, Cytokeratin 14, EBS3, K14, Keratin 14, and KRT14. This antibody recognizes Human antigen. The Keratin 5 &14 Antibody has been validated for the following applications: Immunohistochemistry, Immunohistochemistry - frozen, and Western Blot.
Description
Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie., skin) and non-keratinizing cells (ie., mesothelial cells). Although not a traditional marker for endothelial cells, cytokeratins have also been found in some microvascular endothelial cells. Atleast 20 different cytokeratins (CK) in the molecular range of 40-70 kDa and isoelectric points of 5-8.5 can be identified using two dimensional gel electrophoresis. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification